The aim of the present study was to formulate and evaluate Zolpidem tartrate microspheres. Zolpidem tartrate is a drug with low biological half life and short duration of action used as Sedative-Hypnotic. Microspheres were prepared by spray drying which provided sustained release of drug for 6 hrs. Eudragit RL100 and Ethyl cellulose were screened on the basis of %yield and drug content. Eudragit RL100 showed desirable results. Two process parameters, Inlet air temperature and Aspiration rate were selected in such a way that the % yield of microspheres was maximum. Formulation optimization was done by using 32 full factorial design. Two parameters, Feed rate and drug to Eudragit RL100 ratio were selected as independent variables and Particle size, Q50 and Q80 as dependent variables. It was observed that as the feed rate was increased particle size was increased. Q50 and Q80 were also increased. And decrease in drug to Eudragit RL100 ratio from 1:2 to 1:6 resulted in increase in particle size. Q50 and Q80 were also increased. Thus both the independent variables had positive effect on the responses. Optimized batch was selected on the basis of these dependent variables and drug content.
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